Hyaluronic Acid for Acne and Other Benefits for the Skin

hyaluronic acid for acne

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Using hyaluronic acid for acne treatment can be your best option if you cannot use traditional creams. This substance is found naturally in numerous tissues and organs of the human body: epidermis, connective tissue, cartilage, synovial fluid, eyes, etc. One of its most important properties is its ability to attract and retain water, which keeps these tissues in good condition.

In most acne scars, there is a loss of skin volume (atrophy), which contributes to the depressed or “etched” appearance of the area where they are formed. This atrophy results from a lack of hyaluronic acid and collagen in the dermis, the intermediate part of the skin, responsible for providing the turgor, volume, and elasticity of healthy skin.

Nowadays, hyaluronic acid treatments are among the most demanded procedures because of their simplicity and, above all, because they leave the skin looking natural. What are its benefits?

Hyaluronic acid is a natural, transparent component found in all body tissues, especially in the skin. Its function is to fill the extracellular matrix between the various fibers. During youth, it is concentrated in large quantities but decreases over time.

In cosmetics, hyaluronic acid is used in the manufacture of creams and gels due to its moisturizing properties.

For this reason, it has become one of the most sought-after active ingredients for skin rejuvenation and wound healing, as evidenced in a study published in the journal ROL of nursing, where it was observed that 80% of the lesions had healed in less than 11 weeks.

Results backed by science

More than a few studies have supported the benefits of hyaluronic acid for the skin. A review published in the scientific journal International Journal of Biological Macromolecules highlights that this substance, alone or combined with lidocaine and other coagents, contributes to facial rejuvenation. It also provides other benefits. Discover them!

10 Benefits of hyaluronic acid for acne and skin care

hyaluronic acid for acne

1. Moisturizing

It ensures skin hydration naturally and permanently, as it has the ability to attract and retain water in the most superficial layers of the skin: the epidermis and dermis. Because of this, it is often used in a large number of creams, serums, or gels that we use daily.

2. Firming

It stimulates the formation of collagen, a protein that alone has the ability to regenerate tissues to restore and maintain skin firmness that has been lost over time. In this way, the fibers that support the skin tissues are reconstituted, and therefore, the skin improves its appearance.

3. Cellular repair

It is used as a wound and decubitus ulcer healing agent in topical application since it facilitates and improves the skin’s healing process.

4. Wrinkle filling

Through its power of attraction and water retention, Hyaluronic acid produces a reduction of wrinkles and expression lines by generating a subcutaneous structure that exerts a tightening effect in the deepest layers of the skin.

It causes a filling effect through vehicles such as gels, creams, serums, or infiltrations to directly fill wrinkles between the eyebrows, nasolabial folds, or other wrinkles.

A study published in 2016 found that over-the-counter anti-wrinkle creams containing hyaluronic acid decreased the depth of wrinkles around the lips and eyes by 10 to 20% over a three-month period.

5. Smoothness

Because of its moisturizing properties, hyaluronic acid leaves the skin moisturized and firm; therefore, this is expressed in a smoother appearance and a much softer feel.

The properties of hyaluronic acid also make it possible to improve skin texture. After application, the skin feels smoother.

6. Facial harmonization

When infiltrated, it mixes with the dermis’ own hyaluronic acid to restore its initial volume. Synthesis is relaunched in the skin by injecting exogenous HA, hyaluronic acid, and collagen, lifting the tissues.

These procedures aim to achieve facial harmony; the application is carried out in the malar area, the upper third of furrows, chin, and mandibular border.

You may want to read: Best At-Home Facials For Acne Removal (and other tips…)

It is also used to fill and contour the lips and cheekbones and smooth the forehead and skin marks. It is even used to reduce severe acne scars and other problems.

7. Facial treatments

It is ideal for maintaining firmness, volume, smoothness, and hydration levels when the skin undergoes aesthetic treatments. It is used as an ingredient in cosmetic products due to its moisturizing properties.

8. Volumizing

It refers to the possibility that this product offers to improve the shape of the lips through infiltrations of only 1 ml in both lips. It can be used to give volume or perform lip contouring.

A study published in the Journal of Cutaneous and Aesthetic Surgery determined that the filler with this substance was well tolerated, efficient, and long-lasting after being used for lip augmentation.

9. Flexibility

About half of the body’s hyaluronic acid is located in the skin, where it binds with water to help retain moisture. For this reason, supplementation with this substance helps keep the skin healthy and supple.

10. Rejuvenation

There is no miracle formula to prevent the signs of aging. But the use of hyaluronic acid has been widely accepted as a supplement to attenuate wrinkles and other signs of aging.

What are the side effects of hyaluronic acid for acne?

hyaluronic acid for acne

This substance is a biocompatible product with multiple favorable results in the field of aesthetics. Its side effects are varied but avoidable in specialized hands.

Nowadays, there is more talk about the side effects because it is one of the most appreciated products to regenerate the skin and give volume to those areas where certain tissues have already been lost. Its use in the area of beauty and personal care has been increasing.

You may want to read: How to Get Rid of Stretch Marks on Butt and Other Parts of Your Body

The person receiving the substance must be aware of certain guidelines to avoid adverse reactions and obtain optimal results. Do you know what these recommendations are and what they are intended to avoid? Here are the details:

After applying hyaluronic acid for acne or other ailments, a series of indications should be followed to avoid side effects. These reactions are not always a direct consequence of the product but also appear because the patient has not taken proper care of himself or has not respected the indications of the professional.

Reddening of the area

As a side effect of hyaluronic acid, Erythema in the area is caused by the trauma of local injections. However, it also depends on the properties of the product used. It is a transient reddening with slight inflammation.

This erythema usually lasts from hours to 2 days. The healing process can be accelerated, and special creams can help stimulate healing after the session.

The side effects of hyaluronic acid are immediate, short-term, and medium-term.


A certain amount of bruising accompanied by swelling is usually expected. They usually don’t last more than a few days. Both adverse effects of hyaluronic acid can be minimized by applying firm pressure and ice packs before, after, or during the session.

You may want to read: What Not to do After Botox (and other insights)

Unnecessary anticoagulant medications or products should be discontinued if the person is taking them. According to studies published in The Journal of Clinical and Aesthetic Dermatology, chances of bruising after dermal fillers are between 19 and 24%.


Asymmetries can be generated by the amount of hyaluronic acid used. This results in a momentary difference in the face volume on each side of the nose, for example, with one area larger than the other.

Allergic and hypersensitivity reactions

These reactions are rare, as hyaluronic acid is a biocompatible product. This means that the body assimilates it without identifying it as an external agent since its components are similar to natural substances in the body. However, allergies can be evidenced by local irritation.

Skin necrosis

Skin necrosis due to compression or obstruction of a blood vessel is a rare complication. The highest risk site for this is between the eyebrows. This region is irrigated by the supratrochlear artery, which does not have strong collateral circulation, so it cannot receive blood elsewhere.

Plastic and Reconstructive Surgeons recommend aspirating with the needle before injecting the filler in a constant back and forth motion. In this way, complications could be prevented.

Short-term Hyaluronic Acid Side Effects

hyaluronic acid for acne

Some side effects of hyaluronic acid appear in the short term but not immediately, such as those mentioned above. This means that a few days pass after application, and then they become evident.

Palpable or visible nodules

Nodules and lumps are common complications resulting from the use of dermal fillers. They are classified as inflammatory or non-inflammatory. Late-onset nodules that become present from 4 weeks to 1 year, or even longer, are usually inflammatory, such as immune responses to hyaluronic acid.

According to the American Journal of Clinical Dermatology, although inflammatory nodules are more common with permanent fillers, they have also been reported to develop after using temporary fillers.

Activation of the herpes simplex virus

In those cases where the lip area of people with herpes is operated on, prophylactic anti-herpes treatment should be performed. This is because one of the side effects of hyaluronic acid is activating the infection lodged in the face’s nerves.

Long-term side effects of hyaluronic acid

Months or even years after the application of hyaluronic acid, complications can still appear. These are the long-term side effects, and, many times, it is difficult to identify their reference to the treatment since the intervening time disorients the diagnosis.


Granulomatous foreign body reactions may develop years after the injection. This process is asymptomatic or is accompanied by erythema and swelling.

Persistent foreign body reactions can be treated with intralesional corticosteroid injections. However, through studies conducted, the American Society for Dermatologic Surgery positions hyaluronidase as a feasible therapeutic for this unwanted effect.

The importance of seeing a professional

There are many strategies to reduce the risk of complications with hyaluronic acid fillers. Good working knowledge of the different side effect profiles by a professional is essential.

Although unwanted reactions are rare when a correct injection technique is used, patients should know that unforeseen adverse sequelae can always occur. It is important to be informed and to respect pre-and post-session indications.

Hyaluronic Acid for Acne and Other Benefits for the Skin
hyaluronic acid for acne

Joel & The Wellness Team

Hey! Joel here; A graduate of Herbalism & Naturopathic Medicine School. My team and I are passionate about finding ways to improve our lives on a daily basis and truly believe in natural alternatives of doing so before seeking traditional medications. However, always consult with your Doctor/Physician first before taking any actions regarding your health. Stay Safe and Healthy!

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